Droplet-based microfluidics are emerging as a useful technology in various fields of biomedicine. Both droplet digital PCR and droplet based culture methods require that droplets are created with either a single DNA molecule or a single cell per droplet. Obviously it is difficult to individually place DNA molecules or cells into droplets, instead people turn to stochastic models to estimate the distribution of cells per droplet, tuning the experimental parameters to achieve an acceptable distribution. In this post I derive a Poisson approximation to this process and demonstrate how to calculate quantities of interest under uncertainty in lab measurements.
When hosting our annual Matzah Hunt event, we wanted to come up with a cool and unusual way of picking teams. We decided that we wanted each participant to complete each puzzle only once and to complete each puzzle with a different partner.
Measure theory is actually really simple. Here are some core concepts of measure theory, introduced in a ridiculously simple way.
I am sitting on a plane from Rome to Philadelphia, marveling at how quickly we can move around the globe. There is a 6 hour time-zone difference between Rome and Philadelphia. My flight took off at 11am in Rome and was set to arrive 9 hours and 45 minutes later at 3:45pm in Philadelphia. This got me thinking, what would your daily schedule look like if you continuously flew west?
A few notes on non-linear least squares in R with code. Example relates to fitting Gompertz models for microbial growth curves.
A rhyming logic puzzle we created.
A few thoughts on how to sample covariance matricies with fixed total variance using hyperspheres!